Microsatellite instability (MSI) analysis of colorectal cancers is clinically useful to identify
patients with hereditary nonpolyposis colorectal cancer (HNPCC) caused by germline …

Abstract In December 1997, the National Cancer Institute sponsored “The International
Workshop on Microsatellite Instability and RER Phenotypes in Cancer Detection and …

Purpose: Microsatellite instability (MSI) is found in 10% to 15% of sporadic colorectal tumors
and is usually caused by defects in DNA mismatch repair (MMR). In 1997, a panel of …

Background: Ubiquitous mutations in microsatellite DNA sequences define a specific type of
genetic instability, termed microsatellite instability (MSI). Various approaches have been …

Microsatellite instability (MSI) analysis is becoming more and more important to detect
sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary …

Alterations of the length of simple repetitive genomic sequences (microsatellite instability,
MSI) characterize a distinct mechanism of colorectal carcinogenesis. Such MSI has been …

PURPOSE: To compare microsatellite instability (MSI) testing with immunohistochemical
(IHC) detection of hMLH1 and hMSH2 in colorectal cancer. PATIENTS AND METHODS …

Background Colorectal tumors caused by failure of the DNA mismatch repair system
commonly show microsatellite instability. Our goals were to compare the performance of two …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …

The molecular biology section of the Hereditary Non-Polyposis Colorectal Cancer study
group-Germany, instituted a multicenter study to test the reliability and quality of …