Eukaryotic messenger RNA is translated via a 5′ cap-dependent initiation mechanism.
Experimental evidence for proteins involved with translation initiation among eukaryotic …

The mRNA 5′ cap is an essential structural feature for translation of eukaryotic mRNA.
Translation is initiated by recognition of the cap by the translation initiation factor eIF4E. To …

The multisubunit translation initiation complex eIF4F contains eIF4E, eIF4A and eIF4G.
eIF4A is an ATP-dependent RNA helicase. eIF4G provides the platform for binding initiation …

The eukaryotic translation initiation factor eIF4E recognizes the mRNA cap, a key step in
translation initiation. Here we have characterized eIF4E from the human parasite …

Protein translation leading to polypeptide synthesis involves three distinct events, namely,
initiation, elongation, and termination. Translation initiation is a multi-step process that is …

Regulation of gene expression in the malaria parasite Plasmodium falciparum is tightly
controlled and little is known about the many steps involved. One step ie translation initiation …

All eukaryotic mRNAs possess a 5′-cap (m7GpppN) that is recognized by a family of cap-
binding proteins. These participate in various processes, such as RNA transport and …

In eukaryotes protein synthesis initiates with the binding of the multimeric translation
initiation complex eIF4F–eIF4E, eIF4A and eIF4G–to the monomethylated cap present on …

The eukaryotic initiation factor 4E (eIF4E) specifically recognizes the 5′ mRNA cap, a rate-
limiting step in the translation initiation process. Although the 7-methylguanosine cap …

Background The eukaryotic parasite Plasmodium falciparum causes millions of malarial
infections annually while drug resistance to common antimalarials is further confounding …