Major depressive disorder (MDD) is associated with circadian rhythm disruption. Yet, no
circadian rhythm biomarkers have been clinically validated for assessing antidepressant …

Group-level studies showed associations between depressive symptoms and circadian
rhythm elements, though whether these associations replicate at the within-person level …

Background Alterations in heart rate (HR) may provide new information about physiological
signatures of depression severity. This 2-year study in individuals with a history of recurrent …

Background Sleep and circadian rhythm disruptions are common in patients with mood
disorders. The intricate relationship between these disruptions and mood has been …

Despite many available treatment options for depression, response rates remain suboptimal.
To improve outcome, circadian markers may be suitable as markers of treatment response …

Introduction Depression is the leading cause of worldwide disability, until now only 3% of
patients with major depressive disorder (MDD) experiences full recovery or remission …

Drug development for mood disorders can greatly benefit from the development of robust,
reliable, and objective biomarkers. The incorporation of smartphones and wearable devices …

Background: Depression is a prevalent mental disorder that is undiagnosed and untreated
in half of all cases. Wearable activity trackers collect fine-grained sensor data characterizing …

Background Depression is common in older people and is associated with underlying brain
change increasing the risk of dementia. Sleep disturbance is frequently reported by those …

Background Disruption of sleep and circadian rhythmicity is a core feature of mood disorders
and might be associated with increased susceptibility to such disorders. Previous studies in …