Background: Shikonin, a small molecule inhibitor of pyruvate kinase 2 (PKM2), has been
demonstrated to play the antitumor effect in various cancers. However, the specific effects …

Shift metabolism profile from mitochondrial oxidative phosphorylation to aerobic glycolysis
(Warburg effect) is a key for tumor cell growth and metastasis. Therefore, suppressing the …

Objective Shikonin is a natural product with many activities, including anti-cancer effects.
Pyruvate kinase type M2 (PKM2) plays a crucial role in the growth of tumor cells. However …

Aims In tumor cells, shikonin treatment has been reported to inhibit glycolysis by
suppressing the activity of pyruvate kinase M2 (PKM2) and to induce apoptosis by …

We recently reported that shikonin and its analogs were a class of necroptotic inducers that
could bypass cancer drug resistance. However, the molecular targets of shikonin are not …

The active ingredient of the traditional Chinese medicine comfrey is shikonin, a
naphthoquinone compound. The focus of this study was to investigate the effect of shikonin …

Increasing evidences indicate that shikonin can suppress the tumor growth. However, the
mechanisms remain elusive. In the present study, we investigated the effects and …

Warburg effect provides energy and material essential for tumor proliferation, the reverse of
Warburg effect provides insights into the development of a novel anti-cancer strategy …

Background/Aim: Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly
overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated …

Abstract Pyruvate kinase 2 (PKM2) and pyruvate dehydrogenase kinase 1 (PDK1) are two
key enzymes in tumor glucose metabolism pathway that not only promote tumor growth and …