[HTML][HTML] The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
Proteasome machinery is a major proteostasis control system in human cells, actively
compensated upon its inhibition. To understand this compensation, we compared global …
compensated upon its inhibition. To understand this compensation, we compared global …
[HTML][HTML] Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex
JR Vangala, SK Radhakrishnan - Journal of Biological Chemistry, 2019 - ASBMB
Inhibition of the proteasome leads to proteotoxic stress, which is characterized by the
buildup of ubiquitinated proteins that cannot be degraded properly. The transcription factor …
buildup of ubiquitinated proteins that cannot be degraded properly. The transcription factor …
[HTML][HTML] Disabling the protease DDI2 attenuates the transcriptional activity of NRF1 and potentiates proteasome inhibitor cytotoxicity
A Northrop, JR Vangala, A Feygin… - International journal of …, 2020 - mdpi.com
Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger
apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of …
apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of …
[HTML][HTML] Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
SK Radhakrishnan, CS Lee, P Young, A Beskow… - Molecular cell, 2010 - cell.com
In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …
[HTML][HTML] Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer
Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer
cells exhibit a heightened dependence on proteasome activity, presumably to support their …
cells exhibit a heightened dependence on proteasome activity, presumably to support their …
[HTML][HTML] The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction
S Koizumi, T Irie, S Hirayama, Y Sakurai, H Yashiroda… - Elife, 2016 - elifesciences.org
In response to proteasome dysfunction, mammalian cells upregulate proteasome gene
expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor …
expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor …
NRF3-POMP-20S proteasome assembly axis promotes cancer development via ubiquitin-independent proteolysis of p53 and retinoblastoma protein
T Waku, N Nakamura, M Koji, H Watanabe… - … and cellular biology, 2020 - Taylor & Francis
Proteasomes are essential protease complexes that maintain cellular homeostasis, and
aberrant proteasomal activity supports cancer development. The regulatory mechanisms …
aberrant proteasomal activity supports cancer development. The regulatory mechanisms …
New addiction to the NRF2‐related factor NRF3 in cancer cells: ubiquitin‐independent proteolysis through the 20S proteasome
A Kobayashi, T Waku - Cancer science, 2020 - Wiley Online Library
Accumulating evidence has revealed that human cancers develop by sequentially mutating
pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer …
pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer …
[HTML][HTML] Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function
Protein quality control is an important component of survival for all cells. The use of
proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally …
proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally …
Regulation of NRF1, a master transcription factor of proteasome genes: Implications for cancer and neurodegeneration
A Northrop, HA Byers… - Molecular Biology of the …, 2020 - Am Soc Cell Biol
The ability to sense proteasome insufficiency and respond by directing the transcriptional
synthesis of de novo proteasomes is a trait that is conserved in evolution and is found in …
synthesis of de novo proteasomes is a trait that is conserved in evolution and is found in …
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