Contributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

RA León-Letelier, R Dou, J Vykoukal… - Clinical …, 2024 - academic.oup.com
Background Increasing evidence implicates microbiome involvement in the development
and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of …

Integrated analysis of microbiome and metabolome reveals signatures in PDAC tumorigenesis and prognosis

Y Fang, X Liu, J Ren, X Wang, F Zhou… - Microbiology …, 2024 - journals.asm.org
Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), is one of the
most malignant tumors of the digestive system. Emerging evidence suggests the …

[HTML][HTML] Decoding the microbiota metabolome in hepatobiliary and pancreatic cancers: Pathways to precision diagnostics and targeted therapeutics

Y Xu, J Le, J Qin, Y Zhang, J Yang, Z Chen, C Li… - Pharmacological …, 2024 - Elsevier
We delve into the critical role of the gut microbiota and its metabolites in the pathogenesis
and progression of hepatobiliary and pancreatic (HBP) cancers, illuminating an urgent need …

The role of microbiome in pancreatic cancer

JJ Li, M Zhu, PC Kashyap, N Chia, NH Tran… - Cancer and Metastasis …, 2021 - Springer
Recent studies of the human microbiome have offered new insights into how the microbiome
can impact cancer development and treatment. Specifically, in pancreatic ductal …

A blood-based metabolomic signature predictive of risk for pancreatic cancer

E Irajizad, A Kenney, T Tang, J Vykoukal, R Wu… - Cell Reports …, 2023 - cell.com
Emerging evidence implicates microbiome involvement in the development of pancreatic
cancer (PaCa). Here, we investigate whether increases in circulating microbial-related …

Metabolic characterization of plasma and cyst fluid from cystic precursors to pancreatic cancer patients reveal metabolic signatures of bacterial infection

A Morgell, JA Reisz, Z Ateeb, H Davanian… - Journal of Proteome …, 2021 - ACS Publications
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5
year survival rate as low as 9%. One factor complicating the management of pancreatic …

Microbiome and pancreatic cancer: Time to think about chemotherapy

J de Castilhos, K Tillmanns, J Blessing, A Laraño… - Gut …, 2024 - Taylor & Francis
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by
late diagnosis, rapid progression, and a high mortality rate. Its complex biology …

A comprehensive review of the current and future role of the microbiome in pancreatic ductal adenocarcinoma

N Merali, T Chouari, K Kayani, CJ Rayner, JI Jimenez… - Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current literature related to the microbiome
and pancreatic ductal adenocarcinoma (PDAC). The aim of this review is to explore the …

[HTML][HTML] Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut

Q Yu, C Jobin, RM Thomas - Neoplasia, 2021 - Elsevier
Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related death in the
United States. As one of the most lethal cancer types, the prognosis for patients diagnosed …

Oncobiosis and microbial metabolite signaling in pancreatic adenocarcinoma

B Kiss, E Mikó, É Sebő, J Toth, G Ujlaki, J Szabó… - Cancers, 2020 - mdpi.com
Pancreatic adenocarcinoma is one of the most lethal cancers in both men and women, with
a median five-year survival of around 5%. Therefore, pancreatic adenocarcinoma represents …