PIB-type ATPases transport heavy metal ions (Cu+, Cu2+, Zn2+, Cd2+, Co2+, etc.) across
biological membranes. Several members of this subfamily are present in plants. Higher …

The Zn/Cd‐transporting ATPase, HMA2, has N‐and C‐terminal domains that can bind Zn
ions with high affinity. Mutant derivatives were generated to determine the significance of …

Arabidopsis thaliana has eight genes encoding members of the type 1B heavy metal–
transporting subfamily of the P-type ATPases. Three of these transporters, HMA2, HMA3 …

HMA2 is a Zn 2+-ATPase from Arabidopsis thaliana. It contributes to the maintenance of
metal homeostasis in cells by driving Zn 2+ efflux. Distinct from P 1B-type ATPases, plant Zn …

The transition metal Zn is essential for many physiological processes in plants, yet at
elevated concentrations this, and the related non-essential metal Cd, can be toxic …

AtHMA1 is a member of the heavy metal‐transporting ATPase family. It exhibits amino acid
sequence similarity to two other Zn (II) transporters, AtHMA2 and AtHMA4, and contains poly …

Abstract The Arabidopsis (Arabidopsis thaliana) Heavy Metal Associated3 (AtHMA3) protein
belongs to the P1B-2 subgroup of the P-type ATPase family, which is involved in heavy …

Manipulation of crops to improve their nutritional value (biofortification) and optimisation of
plants for removal of toxic metals from contaminated soils (phytoremediation) are major …

Since copper (Cu) is essential in key physiological oxidation reactions, organisms have
developed strategies for handling Cu while avoiding its potentially toxic effects. Among the …

The P1B-type heavy metal ATPases (HMAs) are diverse in terms of tissue distribution,
subcellular localization, and metal specificity. Functional studies of HMAs have shown that …