AIMS We identified an autosomal dominant non-sense mutation (R225X) in exon 4 of the
lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated …

Background Precision medicine is an emerging approach to disease treatment and
prevention that takes into account individual variability in the environment, lifestyle, and …

Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure and heart
transplantation. A portion of familial DCM is due to mutations in the LMNA gene encoding …

Abstract Lamin A/C (LMNA) is one of the most frequently mutated genes associated with
dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited …

Mutations in the LMNA gene (encoding lamin A/C) are a significant cause of familial
arrhythmogenic cardiomyopathy. Although the penetrance is high, there is considerable …

Mutations in LMNA, the gene that encodes lamin A and C, causes LMNA-related dilated
cardiomyopathy (DCM) or cardiolaminopathy. LMNA is expressed in endothelial cells (ECs); …

Rationale: Mutations in the LMNA gene, encoding LMNA (lamin A/C), are responsible for
laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

Abstract Lamin A/C gene (LMNA)-related familial dilated cardiomyopathy (fDCM) is an
aggressive heart disease that often leads to transplantation and sudden death. The aim of …

Tight control of cell fate choices is crucial for normal development. Here we show that lamin
A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which …