Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

JW Rowland, GWJ Hawryluk, B Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …

[HTML][HTML] Recent advances in managing a spinal cord injury secondary to trauma

CS Ahuja, AR Martin, M Fehlings - F1000Research, 2016 - ncbi.nlm.nih.gov
Traumatic spinal cord injuries (SCIs) affect 1.3 million North Americans, producing
devastating physical, social, and vocational impairment. Pathophysiologically, the initial …

Concise review: Spinal cord injuries: how could adult mesenchymal and neural crest stem cells take up the challenge?

V Neirinckx, D Cantinieaux, C Coste, B Rogister… - Stem …, 2014 - academic.oup.com
Since several years, adult/perinatal mesenchymal and neural crest stem cells have been
widely used to help experimental animal to recover from spinal cord injury. More …

Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells

D Garbossa, M Boido, M Fontanella, C Fronda… - Neurosurgical …, 2012 - Springer
Spinal cord injury (SCI) often results in significant dysfunction and disability. A series of
treatments have been proposed to prevent and overcome the formation of the glial scar and …

Stem cell therapies for acute spinal cord injury in humans: a review

MC Jin, ZA Medress, TD Azad, VM Doulames… - Neurosurgical …, 2019 - thejns.org
Recent advances in stem cell biology present significant opportunities to advance clinical
applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the …

Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Delving into the recent advancements of spinal cord injury treatment: a review of recent progress

JA Flack, KD Sharma, JY Xie - Neural regeneration research, 2022 - journals.lww.com
Spinal cord injury (SCI) research is a very complex field lending to why reviews of SCI
literatures can be beneficial to current and future researchers. This review focuses on recent …

Update on the treatment of spinal cord injury

DC Baptiste, MG Fehlings - Progress in brain research, 2007 - Elsevier
Acute spinal cord injury (SCI) is a devastating neurological disorder that can affect any
individual at a given instance. Current treatment options for SCI include the use of high dose …

[HTML][HTML] Cellular treatments for spinal cord injury: the time is right for clinical trials

MG Fehlings, R Vawda - Neurotherapeutics, 2011 - Elsevier
More than 1 million people in the United States live with a spinal cord injury (SCI). Despite
medical advances, many patients with SCIs still experience substantial neurological …

[HTML][HTML] Current status of experimental cell replacement approaches to spinal cord injury

E Eftekharpour, S Karimi-Abdolrezaee… - Neurosurgical focus, 2008 - thejns.org
✓ Despite advances in medical and surgical care, the current clinical therapies for spinal
cord injury (SCI) are largely ineffective. During the last 2 decades, the search for new …