Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

than another. If residues 1–11 in Fig. 1b Page 1 @e 1997 Nature Publishing Group http://www.nature.com/nsmb
because a few residues at one end pass on one side of a neighbouring strand rather than …

The emergence of functional cooperation between the three main classes of biomolecules–
nucleic acids, peptides and lipids–defines life at the molecular level. However, how such …

De novo emergence demands a transition from disordered polypeptides into structured
proteins with well-defined functions. However, can polypeptides confer functions of …

Conspectus In the quest to understand prebiotic catalysis, different molecular entities, mainly
minerals, metal ions, organic cofactors, and ribozymes, have been implied as key players. Of …

In this review the idea of a “Peptide/Protein World” preceding the widely rooted idea of the
“RNA world” is presented and elaborated. To support this idea, the formation of the building …

The origin of RNA is one of the most formidable problems facing prebiotic chemists. We
consider RNA as a product of evolution, as opposed to the more conventional view of RNA …

The chemistry of abiotic nucleotide synthesis of RNA and DNA in the context of their
prebiotic origins on early earth is a continuing challenge. How did (or how can) the …

The RNA world concept is one of the most fundamental pillars of the origin of life theory,–. It
predicts that life evolved from increasingly complex self-replicating RNA molecules,,. The …