The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …

The endoplasmic reticulum (ER) produces about 40% of the nucleated cell's proteome. ER
size and content in molecular chaperones increase upon physiologic and pathologic …

The ER's capacity to process proteins is limited, and stress caused by accumulation of
unfolded and misfolded proteins (ER stress) contributes to human disease. ER stress elicits …

The endoplasmic reticulum (ER) is a key site for lipid biosynthesis and folding of nascent
transmembrane and secretory proteins. These processes are maintained by careful …

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded
protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits …

The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells. It is
deputed to lipid and protein biosynthesis, calcium storage, and the detoxification of various …

Throughout their life, cells must maintain homeostasis while facing constantly fluctuating
demands on their different organelles. A major mechanism for the homeostatic control of …

The eukaryotic endoplasmic reticulum (ER) maintains protein homeostasis by eliminating
unwanted proteins through the evolutionarily conserved ER-associated degradation (ERAD) …

The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental
functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and …

Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the
endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy …