Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and
transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating …

Renal fibrosis is a major hallmark of chronic kidney disease, regardless of the initial causes,
and prominent renal fibrosis predicts poor prognosis for renal insufficiency. Transforming …

Elevated expression of the multifunctional cytokine transforming growth factor β1 (TGF-β1) is
causatively linked to kidney fibrosis progression initiated by diabetic, hypertensive …

In progressive kidney diseases, fibrosis represents the common pathway to end-stage
kidney failure. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has …

Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic
diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream …

Renal fibrosis is a common irreversible process of chronic kidney disease (CKD)
characterized by uncontrolled deposits of extracellular matrix, replacement of cellular …

Chronic kidney disease (CKD) was a major public health problem worldwide. Renal fibrosis,
especially tubulointerstitial fibrosis, is final manifestation of CKD. Many studies have …

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates a wide
variety of cellular functions, including cell growth, cellular differentiation, apoptosis, and …

Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD).
Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal …

Transforming growth factor-β1 (TGFβ1) is recognized as both a fibrogenic and inflammatory
cytokine and plays a critical role in the kidney pathophysiology. The dysregulation of TGFβ1 …