Highlights•The reductionist drug discovery approach entails high attrition rates.•Topology-
based pathway analysis can unravel the disease mechanism (s).•Candidate targets can be …

Identification of novel targets is a critical first step in the drug discovery and development
process. Most diseases such as cancer, metabolic disorders, and neurological disorders are …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

One of the major challenges of drug discovery today is the poor understanding of the
detailed molecular mechanisms underlying both disease progression and drug action …

Despite the dramatic increase of global spending on drug discovery and development, the
approval rate for new drugs is declining, due chiefly to toxicity and undesirable side effects …

Introduction: Advances in genomics technologies are providing a very large amount of data
on genome-wide gene expression profiles, protein molecules and their interactions with …

Recent advances in biomedical research, genomics and bioinformatics have given the
pharmaceutical and biotechnology industries new promises and expectations: providing …

Conventional drug discovery requires identifying a protein target believed to be important for
disease mechanism and screening compounds for those that beneficially alter the target's …

Systems biology promises to impact significantly on the drug discovery process. One of its
ultimate goals is to provide an understanding of the complete set of molecular mechanisms …

Network-based drug discovery aims at harnessing the power of networks to investigate the
mechanism of action of existing drugs, or new molecules, in order to identify innovative …