[HTML][HTML] Evolocumab prevents atrial fibrillation in rheumatoid arthritis rats through restraint of PCSK9 induced atrial remodeling
X Han, Y Gao, M He, Y Luo, Y Wei, Y Duan… - Journal of advanced …, 2023 - Elsevier
Introduction Proprotein convertase subtilisin/kexin type 9 (PCSK9) is implicated in the
pathogenesis and progression of autoimmune disease. Patients with rheumatoid arthritis …
pathogenesis and progression of autoimmune disease. Patients with rheumatoid arthritis …
PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway
M Yu, W Tang, W Liang, B Xie, R Gao, P Ding… - International …, 2023 - Elsevier
Proprotein convertase subtilisin kexin type 9 (PCSK9) was characterized as a protein
regulating circulating cholesterol metabolism; however, recent studies demonstrated a role …
regulating circulating cholesterol metabolism; however, recent studies demonstrated a role …
[HTML][HTML] Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms
J Frostegård, S Ahmed, I Hafström, S Ajeganova… - Arthritis Research & …, 2021 - Springer
Background Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor
(LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological …
(LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological …
Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis
F Wang, L Wang, H Jiang, X Chang, J Pan - The Journal of …, 2015 - jrheum.org
Objective. To assess the effect of proprotein convertase subtilisin/kexin type 6 (PCSK6) in
the synovial fibroblasts of rheumatoid arthritis (RA). PCSK6 is a proteinase implicated in the …
the synovial fibroblasts of rheumatoid arthritis (RA). PCSK6 is a proteinase implicated in the …
[HTML][HTML] Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
W Xie, J Li, H Du, J Xia - Arthritis research & therapy, 2023 - Springer
Background In addition to decreasing the level of cholesterol, proprotein convertase subtilis
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …
Circulating PCSK9 relates to aggravated disease activity, Th17/Treg imbalance, and predicts treatment outcome of conventional synthetic DMARDs in rheumatoid …
Y Meng, X Zheng, Z Zhang, H Geng, X Li - Irish Journal of Medical Science …, 2023 - Springer
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates inflammatory
response and CD4+ T cell differentiation in autoimmune diseases, while its clinical role in …
response and CD4+ T cell differentiation in autoimmune diseases, while its clinical role in …
The role of PCSK9 in inflammation, immunity, and autoimmune diseases
J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Statins have pleiotropic effects, being both anti-inflammatory and
immunomodulatory. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the low-density …
immunomodulatory. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the low-density …
PCSK9 and inflammation: their role in autoimmune diseases, with a focus on rheumatoid arthritis and systemic lupus erythematosus
S Ministrini, F Carbone - Current Medicinal Chemistry, 2022 - ingentaconnect.com
Despite a clear epidemiological link between autoimmune disease and cardiovascular (CV)
risk exists, pathophysiological explanations are extremely complex and far from being …
risk exists, pathophysiological explanations are extremely complex and far from being …
[PDF][PDF] PCSK9 promotes the secretion of pro-inflammatory cytokines by macrophages to aggravate H/R-induced cardiomyocyte injury via activating NF-? B signalling.
CL Yang, YD Zeng, ZX Hu, H Liang - General Physiology & …, 2020 - researchgate.net
The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to
be involved in regulating the levels of inflammatory markers and apoptosis in macrophages …
be involved in regulating the levels of inflammatory markers and apoptosis in macrophages …
Effect of PCSK9 Monoclonal antibody versus placebo/ezetimibe on atrial fibrillation in patients at high cardiovascular risk: a Meta-Analysis of 26 Randomized …
S Yang, W Shen, HZ Zhang, CX Wang, PP Yang… - … Drugs and Therapy, 2023 - Springer
Background Patients at high cardiovascular risk are closely associated with an increased
risk of atrial fibrillation (AF). Whether proprotein convertase subtilisin/kexin type 9 …
risk of atrial fibrillation (AF). Whether proprotein convertase subtilisin/kexin type 9 …
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