Differentiating cells interact with their extracellular environment over time. Chondrocytes
embed themselves in a proteoglycan (PG)-rich matrix, then undergo a developmental …

The long bones of the vertebrate body are built by the initial formation of a cartilage template
that is later replaced by mineralized bone. The proliferation and maturation of the skeletal …

During endochondral ossification, chondrocytes embed themselves in a proteoglycan-rich
matrix during the proliferation-maturation transition. Accumulating evidence shows that …

In vitro differentiation of mesenchymal stem cells (MSCs) into chondrogenic cells and their
transplantation is promising as a technique for the treatment of cartilaginous defects. But the …

Research on the genetic mechanisms underlying human skeletal development and disease
have largely relied on studies in mice. However, recently the zebrafish has emerged as a …

Endochondral ossification is the process by which the embryonic cartilaginous model of
most bones contributes to longitudinal growth and is gradually replaced by bone. During …

Condylar articular cartilage in mouse temporomandibular joint develops from progenitor
cells near the articulating surface that proliferate, undergo chondrogenesis and mature into …

Glypicans are a family of glycosylphosphatidylinositol (GPI)-anchored, membrane-bound
heparan sulfate (HS) proteoglycans. Their biological roles are only partly understood …

The skeletal elements of the axial and appendicular skeleton are preformed as cartilage
templates by a mechanism called endochondral ossification. During this process, a cartilage …

Much of the vertebrate skeleton develops from cartilage templates that are progressively
remodeled into bone. Lineage tracing studies in mouse suggest that chondrocytes within …