Chlamydia trachomatis plasmid-encoded protein pORF5 activates unfolded protein response to induce autophagy via MAPK/ERK signaling pathway

Y Wen, F Luo, Y Zhao, S Su, M Shu, Z Li - Biochemical and biophysical …, 2020 - Elsevier
Chlamydia trachomatis (C. trachomatis) is an obligate intracellular organism that depends
on nutrients from the host cell for their replication and proliferation. Therefore, the interaction …

Chlamydia trachomatis pORF5 plasmid-encoded protein regulates autophagy and apoptosis of HeLa cells

B He, Y Zhao, X Yang, S Su, Y Wen… - Biotechnology & …, 2019 - Taylor & Francis
Chlamydia trachomatis is an important human pathogen responsible for a variety of
important diseases. pORF5, a plasmid protein in C. trachomatis, has been reported to …

The Roles of Unfolded Protein Response Pathways in Chlamydia Pathogenesis

Z George, Y Omosun, AA Azenabor… - The Journal of …, 2017 - academic.oup.com
Chlamydia is an obligate intracellular bacterium that relies on host cells for essential
nutrients and adenosine triphosphate (ATP) for a productive infection. Although the unfolded …

Chlamydia psittaci induces autophagy in human bronchial epithelial cells via PERK and IRE1α, but not ATF6 pathway

L Chen, Q Huang, Q Bai, T Tong, Y Zhou, Z Li… - Infection and …, 2022 - Am Soc Microbiol
Chlamydia psittaci is an important pathogen that causes chronic and atypical pneumonia in
humans. Autophagy and the unfolded protein response (UPR) are important mechanisms for …

[HTML][HTML] Chlamydia trachomatis Plasmid Protein pORF5 Up-Regulates ZFAS1 to Promote Host Cell Survival via MAPK/p38 Pathway

Y Wen, H Chen, F Luo, L Zhao, M Shu, S Su… - Frontiers in …, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in many
diseases. However, few studies have shown that lncRNAs take part in the pathogenesis of …

Chlamydia trachomatis plasmid-encoded protein pORF5 protects mitochondrial function by inducing mitophagy and increasing HMGB1 expression

W Lei, Q Li, S Su, J Bu, Q Huang, Z Li - Pathogens and disease, 2017 - academic.oup.com
Chlamydia trachomatis, an obligate intracellular pathogen, has various effective strategies to
regulate host cell death signalling pathways that ensure completion of their growth cycle …

[HTML][HTML] Identification of proteins interacting with pORF5 in the pathogenesis of C. trachomatis

Y Zou, W Dai, W Lei, S Su, Q Huang… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Objective: This study is to identify and investigate the proteins interacting with pORF5
implicated in the pathogenesis of C. trachomatis. Methods: The isobaric tags for relative and …

Inflammatory mechanism of Chlamydia trachomatis-infected HeLa229 cells regulated by Atg5

F Wang, L Zhang, X Lu, Q Zhu, T Shi, R Lu, P Yu… - Biochemical and …, 2019 - Elsevier
The relation between autophagy and Chlamydia trachomatis infection remain inconclusive.
In order to further understand the role of autophagy in C. trachomatis-infected cells. Atg5 …

ATG9A supports Chlamydia trachomatis infection via autophagy-independent mechanisms

M Suzuki, T Funakoshi, K Kumagai… - Microbiology …, 2023 - Am Soc Microbiol
Chlamydia trachomatis infection can be regulated by autophagy-related (ATG) genes. Here,
we found that the depletion of ATG9A, one of the core ATG genes, in HeLa cells suppressed …

Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites

L Galluzzi, A Diotallevi, M Magnani - Future science OA, 2017 - Future Science
Perturbations of the physiological status of the endoplasmic reticulum (ER) trigger a specific
response known as the ER stress response or unfolded protein response (UPR). In …