It is critical to discover why some people's cognitive abilities age better than others'. We
applied multivariate growth curve models to data from a narrow-age cohort measured on a …

Discovering why some people's cognitive abilities decline more than others is a key
challenge for cognitive ageing research. The most effective strategy may be to address …

The present longitudinal multi-cohort study examines whether interindividual variability in
cognitive performance and change increases in old age, and whether associations among …

Aging-related declines occur in many different domains of cognitive function during middle
and late adulthood. However, whether a global dimension underlies individual differences in …

Background: This paper briefly summarizes recent evidence on the nature of cognitive
decline, the variability in individual responses to ageing, and risk factors known to affect the …

Most people's cognitive abilities decline with age, with significant and partly genetically
driven, individual differences in rate of change. Although APOE ɛ4 and genetic scores for …

Aging-related changes occur for multiple domains of cognitive functioning. An accumulating
body of research indicates that, rather than representing statistically independent …

Longitudinal data from the MacArthur Study of Successful Aging were used to test for
interactions between education and apolipoprotein E (APOE) genotype with respect to time …

Polygenic scores can be used to distil the knowledge gained in genome-wide association
studies for prediction of health, lifestyle, and psychological factors in independent samples …

Objectives Identification of risk factors for Alzheimer disease (AD) is critical for establishing
effective diagnostic and therapeutic strategies. Carrying the ɛ4 allele of the apolipoprotein E …