[HTML][HTML] A frontal-vagal network theory for major depressive disorder: implications for optimizing neuromodulation techniques

TA Iseger, NER van Bueren, JL Kenemans, R Gevirtz… - Brain stimulation, 2020 - Elsevier
Abstract Major Depressive Disorder (MDD) is a psychiatric disorder characterized by high
comorbidity with cardiovascular disease. Furthermore, a combination of high heart rate (HR) …

[HTML][HTML] Investigating high-and low-frequency neuro-cardiac-guided TMS for probing the frontal vagal pathway

M Kaur, JA Michael, KE Hoy, BM Fitzgibbon, MS Ross… - Brain stimulation, 2020 - Elsevier
Background Investigating approaches for determining a functionally meaningful dorsolateral
prefrontal cortex (DLPFC) stimulation site is imperative for optimising repetitive transcranial …

Neuro-Cardiac-Guided TMS (NCG-TMS): Probing DLPFC-sgACC-vagus nerve connectivity using heart rate–First results

TA Iseger, F Padberg, JL Kenemans, R Gevirtz, M Arns - Brain stimulation, 2017 - Elsevier
Background Given that many studies suggest a role of DLPFC-sgACC connectivity in
depression and prior research demonstrating that neuromodulation of either of these nodes …

Repetitive transcranial magnetic stimulation for treatment resistant depression: Re-establishing connections

RJ Anderson, KE Hoy, ZJ Daskalakis… - Clinical …, 2016 - Elsevier
Repetitive transcranial magnetic stimulation (rTMS) is a relatively recent addition to the
neurostimulation armamentarium for treating individuals suffering from treatment refractory …

Depression and cardiovascular autonomic control: a matter of vagus and sex paradox

E Tobaldini, A Carandina, E Toschi-Dias, L Erba… - Neuroscience & …, 2020 - Elsevier
Depression is a well-established stress-related risk factor for several diseases, mainly for
those with cardiovascular outcomes. The mechanisms that link depression disorders with …

New targets for rTMS in depression: a review of convergent evidence

J Downar, ZJ Daskalakis - Brain stimulation, 2013 - Elsevier
Although rTMS is moving steadily into the mainstream as a treatment for medically refractory
depression, its efficacy continues to lag behind that of more invasive neuromodulation …

Distinct symptom-specific treatment targets for circuit-based neuromodulation

SH Siddiqi, SF Taylor, D Cooke… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: Treatment of different depression symptoms may require different brain
stimulation targets with different underlying brain circuits. The authors sought to identify such …

Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial

R Morriss, PM Briley, L Webster, M Abdelghani… - Nature Medicine, 2024 - nature.com
Disruption in reciprocal connectivity between the right anterior insula and the left
dorsolateral prefrontal cortex is associated with depression and may be a target for …

Default mode network mechanisms of transcranial magnetic stimulation in depression

C Liston, AC Chen, BD Zebley, AT Drysdale… - Biological …, 2014 - Elsevier
Background Repetitive transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal
cortex (DLPFC) is an established treatment for depression, but its underlying mechanism of …

Targeted transcranial theta-burst stimulation alters fronto-insular network and prefrontal GABA

SJ Iwabuchi, F Raschke, DP Auer, PF Liddle… - Neuroimage, 2017 - Elsevier
Repetitive transcranial magnetic stimulation (rTMS) has been used worldwide to treat
depression. However, the exact physiological effects are not well understood …