Abstract Superoxide dismutase 1 (Sod1) has been known for nearly half a century for
catalysis of superoxide to hydrogen peroxide. Here we report a new Sod1 function in …

SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of
superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential …

During cellular respiration, radicals, such as superoxide, are produced, and in a large
concentration, they may cause cell damage. To combat this threat, the cell employs the …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

Many breast cancer cells typically exhibit lower expression of manganese superoxide
dismutase (MnSOD) compared to the normal cells from which they arise. This decrease can …

Oxidative stress leads to the up-regulation of many antioxidant enzymes including Cu, Zn
superoxide dismutase (SOD1) via transcriptional mechanisms; however, few examples of …

Numerous short-lived and highly reactive oxygen species (ROS) such as superoxide (O2−),
hydroxyl radical, and hydrogen peroxide are continuously generated in vivo. Depending …

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

Extracellular superoxide dismutase (SOD3), a secretory copper-containing antioxidant
enzyme, plays an important role in various oxidative stress-dependent cardiovascular …

Reactive oxygen species (ROS) such as superoxide radicals are responsible for the
pathogenesis of various human diseases. ROS are generated during normal metabolic …