Background Chronic cerebral hypoperfusion (CCH) is a major risk factor for vascular
dementia (VaD). There are currently no broadly effective prevention or treatment strategies …

Vascular dementia is the highly devastating neurodegenerative disorder after Alzheimer's
disease (AD) and mainly found in aged people but the effectual therapeutic target is still not …

Vascular dementia (VaD) is characteristic of chronic brain ischemia and progressive
memory decline, which has a high incidence in the elderly. However, there are no effective …

Background: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and
blood-brain barrier (BBB) impairment in vascular dementia (VaD). However, the relationship …

Background Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for
which effective therapy remains inadequate. Persistent inflammatory responses and …

The endocannabinoid system has been suggested to elicit signals that defend against
several disease states including excitotoxic brain damage. Besides direct activation with …

Traumatic brain injury (TBI) is an increasingly prevalent condition affecting people of all
ages and genders. The impairment of spatial learning and memory is one of the most …

Abstract Endocannabinoids [2-arachidonoylglycerol (2-AG) and N-
arachidonoylethanolamine (AEA)], endogenously produced arachidonate-based lipids, are …

The modulation of endocannabinoid (EC) levels and the activation of cannabinoid receptors
are seen as promising therapeutic strategies in a variety of diseases, including Alzheimer's …

The type 2 cannabinoid receptor (CB2R) was recently shown to mediate neuroprotection in
ischemic injury. However, the role of CB2Rs in the central nervous system, especially …