Introduction Diffuse midline gliomas (DMG) and diffuse hemispheric glioma (DHG) are both
rare tumors characterized and recognized for specific alterations of histone 3 including …

Pediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their
aggressive pathophysiology and limited treatment options. Among them, H3 K27-altered …

Simple Summary H3K27M-mutant diffuse midline glioma is a rare childhood cancer
originating in midline brain structures. The H3K27M mutation substitutes an amino acid on …

Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a
dismal outcome. Recently, a new subtype of midline gliomas has been described with …

Background “Diffuse midline glioma (DMG), H3 K27M-mutant” is a new tumor entity
established in the 2016 WHO classification of Tumors of the Central Nervous System that …

Introduction H3 K27-altered diffuse midline glioma (DMG) is the most common malignant
brainstem tumor in the pediatric population. Despite enormous preclinical and clinical …

Abstract Purpose of Review H3K27M is a frequent histone mutation within diffuse midline
gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO …

Purpose Diffuse midline gliomas (DMG) with H3K27M mutations have been identified as a
rare distinctive entity with unique genetic features, varied molecular alterations, and poor …

Background Diffuse midline glioma with histone H3K27M mutation (H3K27M DMG) is a
recently recognized World Health Organization grade IV glioma with a dismal prognosis …

H3K27-altered diffuse midline glioma (DMG H3K27-altered) is a relatively newly-designated
WHO entity which primarily affects the midline structures of the central nervous system …