Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome

J Faro, R Romero, G Schwenkel… - Biology of …, 2019 - academic.oup.com
Intra-amniotic inflammation is strongly associated with spontaneous preterm labor and birth,
the leading cause of perinatal mortality and morbidity worldwide. Previous studies have …

Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes

N Gomez-Lopez, R Romero… - Biology of …, 2019 - academic.oup.com
Sterile intra-amniotic inflammation is commonly observed in patients with spontaneous
preterm labor, a syndrome that commonly precedes preterm birth, the leading cause of …

The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome

K Motomura, R Romero, V Garcia-Flores… - Molecular human …, 2020 - academic.oup.com
Sterile intra-amniotic inflammation is a clinical condition frequently observed in women with
preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide …

[HTML][HTML] The placental NLRP3 inflammasome and its downstream targets, caspase-1 and interleukin-6, are increased in human fetal growth restriction: implications for …

I Alfian, A Chakraborty, HEJ Yong, S Saini, RWK Lau… - Cells, 2022 - mdpi.com
Fetal growth restriction (FGR) is commonly associated with placental insufficiency and
inflammation. Nonetheless, the role played by inflammasomes in the pathogenesis of FGR is …

A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B

J Galaz, K Motomura, R Romero, Z Liu… - Translational …, 2023 - Elsevier
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A
substantial number of spontaneous preterm births occur in the context of sterile intra …

Inflammasomes: their role in normal and complicated pregnancies

N Gomez-Lopez, K Motomura, D Miller… - The Journal of …, 2019 - journals.aai.org
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

A role for the inflammasome in spontaneous preterm labor with acute histologic chorioamnionitis

N Gomez-Lopez, R Romero, YI Xu… - Reproductive …, 2017 - journals.sagepub.com
Inflammasomes are cytosolic multiprotein complexes that orchestrate inflammation in
response to pathogens and endogenous danger signals. Herein, we determined whether …

[HTML][HTML] Role of the NLRP3 inflammasome in preeclampsia

K Shirasuna, T Karasawa, M Takahashi - Frontiers in endocrinology, 2020 - frontiersin.org
Reproduction involves tightly regulated series of events and the immune system is involved
in an array of reproductive processes. Disruption of well-controlled immune functions leads …

[HTML][HTML] Fetal and maternal NLRP3 signaling is required for preterm labor and birth

K Motomura, R Romero, J Galaz, L Tao… - JCI insight, 2022 - ncbi.nlm.nih.gov
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …

Uric acid induces trophoblast IL‐1β production via the inflammasome: implications for the pathogenesis of preeclampsia

MJ Mulla, K Myrtolli, J Potter, C Boeras… - American journal of …, 2011 - Wiley Online Library
Citation Mulla MJ, Myrtolli K, Potter J, Boeras C, Kavathas PB, Sfakianaki AK, Tadesse S,
Norwitz ER, Guller S, Abrahams VM. Uric acid induces trophoblast IL‐1β production via the …