A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …

Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–
cell interactions in processes as diverse as tissue development, immune cell trafficking and …

Topobiology posits that morphogenesis is driven by differential adhesive interactions among
heterogeneous cell populations. This paradigm has been revised to include force …

Reconstituting tissues from their cellular building blocks facilitates the modeling of
morphogenesis, homeostasis and disease in vitro. Here we describe DNA-programmed …

Synthetic biology provides an opportunity for the construction and exploration of alternative
solutions to biological problems-solutions different from those chosen by natural life. To this …

Organoids form through self-organization processes in which initially homogeneous
populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern …

Increased control of biological growth and form is an essential gateway to transformative
medical advances. Repairing of birth defects, restoring lost or damaged organs, normalizing …

Multicellular organs comprise differentiated cell types with discrete yet interdependent
functions. The cells' spatial arrangements and interconnectivities, both critical elements of …

The complexity of the human body derives from numerous modular building blocks
assembled hierarchically across multiple length scales. These building blocks, spanning …

Organoids are multicellular structures that can be derived from adult organs or pluripotent
stem cells. Early versions of organoids range from simple epithelial structures to complex …