Estradiol is the “prototypic” sex hormone of women. Yet, women have another sex hormone,
which is often disregarded: Progesterone. The goal of this article is to provide a …

Rationale Reproductive mood disorders, including premenstrual dysphoria (PMD) and
postpartum depression (PPD), are characterized by affective dysregulation that occurs …

Rationale Allopregnanolone effects on mood in postmenopausal women are unclear thus
far. Objectives Allopregnanolone is a neuroactive steroid with contradictory effects …

Hormonal contraceptives are used worldwide by more than 100 million women. Some
studies have been published about the possible appearance of depressive symptoms when …

Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high
worldwide prevalence and serious long-term negative outcomes for both mothers and …

Background: This study was designed to examine basal and stress-induced levels of the
neuroactive progesterone metabolite, allopregnanolone, in women with premenstrual …

Objective Preclinical evidence indicates that rapid changes in levels of allopregnanolone,
the predominant metabolite of progesterone, confer dramatic behavioral changes and may …

OBJECTIVE: To evaluate the anxiolytic 3α-5α-reduced progesterone metabolite
allopregnanolone in the luteal phase of the menstrual cycle in women with premenstrual …

Context Allopregnanolone is a metabolite from progesterone and a positive modulator of the
GABA A receptor. This endogenous steroid may induce negative mood in sensitive women …

Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood
and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone …