Extracellular vesicles have emerged as important mediators of cell-to-cell communication in
the pathophysiology of fibrotic diseases. One such disease is Peyronie's disease (PD), a …

Objectives A key effector cell in the pathophysiology of Peyronie's disease (PD) is the
myofibroblast. Whilst the role of extracellular vesicles (EVs) and the secretome has been …

The myofibroblast is a highly specialized cell type that plays a critical role during normal
tissue wound healing, but also contributes pathologically to chronic inflammatory conditions …

The conjunctive presence of mechanical stress and active transforming growth factor β1
(TGF-β1) is essential to convert fibroblasts into contractile myofibroblasts, which cause …

The differentiation of resident fibroblasts to myofibroblasts is central to wound healing. In the
context of organ fibrosis, however, persistence of these myofibroblasts is associated with …

Developing methods to study tissue mechanics and myofibroblast activation may lead to
new targets for therapeutic treatments that are urgently needed for fibrotic disease …

Myofibroblasts are critical to processes involved in normal wound healing and during
pathological fibrosis. They transdifferentiate from fibroblasts, and in doing so become …

Transforming growth factor‐β (TGF‐β) is a multifunctional cytokine which stimulates the
differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound …

Myofibroblasts are central mediators of fibrosis. Typically derived from resident fibroblasts,
myofibroblasts represent a heterogeneous population of cells that are principally defined by …

Activation of myofibroblast rich stroma is a rate-limiting step essential for cancer progression.
The responsible factors are not fully understood, but TGFβ1 is probably critical. A proportion …