Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human
neutrophils, monocytes, macrophages, and endothelial cells. Human neutrophil elastase is …

Human neutrophil elastase (HNE) is a serine protease that has been implicated in the
abnormal turnover of connective tissue proteins and has been described as an important …

Pathogenesis of chronic inflammatory diseases is associated with excessive elastase
release through neutrophil degranulation. In the present study, inhibition of human …

Human neutrophil elastase (HNE) is a serine protease, which is present in its active form in
inflamed tissue as well as in psoriatic lesions. In extension of our research on natural …

Elastases are a broad group of enzymes involved in the lysis of elastin, the main component
of elastic fibres. They are produced and released in the human body, mainly by neutrophils …

Human neutrophil elastase (HNE), a serine protease with broad target specificity, is the only
enzyme responsible for the degradation of elastin which is an insoluble elastic fibrous …

Human neutrophil elastase (HNE) is an important therapeutic target for treatment of
pulmonary diseases. Previously, we identified novel N-benzoylindazole derivatives as …

The imbalance between human neutrophil elastase (HNE) and endogenous serine
proteinase inhibitors is considered to cause a variety of HNE-mediated inflammatory …

Human neutrophil elastase (HNE) is a major cause of the destruction of tissues in cases of
several different chronic andinflammatory diseases. Overexpression of the elastase enzyme …

Compounds that can effectively inhibit the proteolytic activity of human neutrophil elastase
(HNE) represent promising therapeutics for treatment of inflammatory diseases. We present …