In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …

Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting
genes and regulatory elements can free themselves from chromosomes and relocate to …

Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

The amplification of oncogenes on extrachromosomal DNA (ecDNA) provides a new
mechanism for cancer cells to adapt to the changes in the tumor microenvironment and …

The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not
found in normal cells. Analysis of clinical samples reveal they are common in most cancers …

In cancer, complex genome rearrangements and other structural alterations, including the
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …

In cancer, oncogenes and surrounding regulatory regions can untether themselves from
chromosomes, forming extrachromosomal DNA particles (ecDNAs). Because of their non …

Highlights•Extrachromosomal DNA (ecDNA) provides a mechanism by which cancer cells
can accelerate intratumour heterogeneity.•ecDNA contain favourable epigenetic …

In cancers, extrachromosomal DNA (ecDNA) has gained renewed interest since its first
discovery, presenting its roles in tumorigenesis. Because of the unique structure and genetic …

Abstract Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of
DNA, is often present in tumor cells. Recent studies have revealed that oncogene …