Knocking out NtSARD1a/1b/1c/1d by CRISPR/CAS9 technology reduces the biosynthesis of salicylic acid (SA) and compromises immunity in tetraploid Nicotiana …

XY Dai, HJ Lan, Y Chen, TY Liu, YT Zhao, JZ Liu - Plant Science, 2024 - Elsevier
Salicylic acid (SA) is a key phyto-hormone that is essential for plant immunity. SARD1
(SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1), a member of the CBP60 …

Negative regulation of resistance protein‐mediated immunity by master transcription factors SARD1 and CBP60g

T Sun, W Liang, Y Zhang, X Li - Journal of integrative plant …, 2018 - Wiley Online Library
Salicylic acid (SA) is an essential defence hormone in plants. Upon pathogen infection,
induced biosynthesis of SA is mediated by Isochorismate synthase 1 (ICS1), whose gene …

[HTML][HTML] Impact of CRISPR/Cas9-induced mutations in nicotine biosynthesis core genes A622 and BBL on tobacco: Reduction in nicotine content and developmental …

J Jeong, E Jeon, YJ Song, MK Hwang, Y Gwak… - Current Plant …, 2024 - Elsevier
Tobacco (Nicotiana tabacum) is known for its psychoactive alkaloid nicotine, which presents
significant public health challenges. Recent research has linked the final stages of nicotine …

[HTML][HTML] CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum

J Gao, G Wang, S Ma, X Xie, X Wu, X Zhang, Y Wu… - Plant molecular …, 2015 - Springer
Genome editing is one of the most powerful tools for revealing gene function and improving
crop plants. Recently, RNA-guided genome editing using the type II clustered regularly …

[HTML][HTML] Nicotine‐free, nontransgenic tobacco (Nicotiana tabacum l.) edited by CRISPR‐Cas9

J Schachtsiek, F Stehle - Plant biotechnology journal, 2019 - ncbi.nlm.nih.gov
Worldwide, approximately 1.1 billion people are smokers and more than 7 million people die
from the negative effects of smoking every year (WHO report, 2017). One of the main natural …

Validation of endogenous U6 promoters for expanding the CRISPR toolbox in Nicotiana tabacum

P Luo, S Li, L Li, Y Li, Y Qiao, X Wu, M Wu… - In Vitro Cellular & …, 2024 - Springer
In the past decade, the clustered regularly interspaced short palindromic repeat paired
associated protein 9 (CRISPR-Cas9) mediated gene editing has been extensively utilized …

CRISPR/Cas9-mediated knockout of NtMYC2a gene involved in resistance to bacterial wilt in tobacco

Z Xiao, W Yang, A Yang, L Deng, R Geng, H Xiang… - Gene, 2024 - Elsevier
MYC2 is a class of bHLH family transcription factors and a major regulatory factor in the JA
signaling pathway, and its molecular function in tobacco has not been reported. In this study …

Nucleoredoxin gene SINRX1 negatively regulates tomato immunity by activating SA signaling pathway

JY Cha, S Uddin, DM Macoy, GI Shin, SY Jeong… - Plant Physiology and …, 2023 - Elsevier
The tomato (Solanum lycopersicum) is widely consumed globally and renowned for its
health benefits, including the reduction of cardiovascular disease and prostate cancer risk …

NtPR1a regulates resistance to Ralstonia solanacearum in Nicotiana tabacum via activating the defense-related genes

Y Liu, Q Liu, Y Tang, W Ding - Biochemical and Biophysical Research …, 2019 - Elsevier
Pathogenesis-related proteins (PRs) are associated with the development of systemic
acquired resistance (SAR) against further infection enforced by fungi, bacteria and viruses …

[HTML][HTML] Next-generation mapping of the salicylic acid signaling hub and transcriptional cascade

J Powers, X Zhang, AV Reyes, R Zavaliev, SL Xu… - bioRxiv, 2024 - ncbi.nlm.nih.gov
For over 60 years, salicylic acid (SA) has been known as a plant immune signal required for
both basal and systemic acquired resistance (SAR). SA activates these immune responses …