Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Co-pathologies play an important role in the expression of the Alzheimer's disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
Alzheimer's disease
JAS Lopez, HM González, GC Léger - Handbook of clinical neurology, 2019 - Elsevier
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …
functional decline associated with age together with a particular neuropathology. It was first …
The development and convergence of co-pathologies in Alzheimer's disease
JL Robinson, H Richardson, SX Xie, ER Suh… - Brain, 2021 - academic.oup.com
Cerebral amyloid angiopathy (CAA), limbic-predominant age-related TDP-43
encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the …
encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the …
Alzheimer's disease neuropathological comorbidities are common in the younger-old
TG Beach, M Malek-Ahmadi - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Background: Clinicopathological studies have demonstrated that Alzheimer's disease
dementia (ADD) is often accompanied by clinically undetectable comorbid …
dementia (ADD) is often accompanied by clinically undetectable comorbid …
Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy …
GG Kovacs, I Milenkovic, A Wöhrer, R Höftberger… - Acta …, 2013 - Springer
Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of
proteins with altered physicochemical properties. The major proteins are amyloid-β (Aβ), tau …
proteins with altered physicochemical properties. The major proteins are amyloid-β (Aβ), tau …
Polygenic hazard scores in preclinical Alzheimer disease
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease
(AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated …
(AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated …
Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer's disease …
Alzheimer's disease patients typically present with multiple co-morbid neuropathologies at
autopsy, but the impact of these pathologies on cognitive impairment during life is poorly …
autopsy, but the impact of these pathologies on cognitive impairment during life is poorly …
Alzheimer's disease including focal presentations
Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most
frequent cause of dementia. It affects 30 million people worldwide. Current research criteria …
frequent cause of dementia. It affects 30 million people worldwide. Current research criteria …
Early-onset Alzheimer disease and its variants
MF Mendez - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
PURPOSE OF REVIEW Early-onset Alzheimer disease (AD) is defined as having an age of
onset younger than 65 years. While early-onset AD is often overshadowed by the more …
onset younger than 65 years. While early-onset AD is often overshadowed by the more …
Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset
A Tort‐Merino, N Falgas, IE Allen… - Annals of Clinical …, 2022 - Wiley Online Library
Objectives Early‐and late‐onset Alzheimer's disease (EOAD and LOAD) share the same
neuropathological traits but show distinct cognitive features. We aimed to explore baseline …
neuropathological traits but show distinct cognitive features. We aimed to explore baseline …