Simple Summary Hepatocellular carcinoma represents the majority of all liver cancers and
the fourth cause of cancer-related deaths worldwide. Despite the progress in diagnostic and …

Liver cancer cell lines are frequently used in vitro tools to test candidate anti-cancer agents
as well as to elucidate mechanisms of liver carcinogenesis. Among such mechanisms is …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Because of their critical role as goalkeepers of hepatic homeostasis, gap junctions are
frequent targets in liver disease. This concept has been demonstrated on many occasions in …

AIM: To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43
messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS: Using a …

Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …