FUNDC1-mediated mitophagy triggered by mitochondrial ROS is partially involved in 1-nitropyrene-evoked placental progesterone synthesis inhibition and …

J Li, X Dong, JY Liu, L Gao, WW Zhang… - Science of The Total …, 2024 - Elsevier
Intrauterine growth retardation (IUGR) is a major cause of perinatal morbidity and mortality.
Previous studies showed that 1-nitropyrene (1-NP), an atmospheric pollutant, induces …

[HTML][HTML] Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in …

HL Zhu, XT Shi, XF Xu, GX Zhou, YW Xiong, SJ Yi… - Redox Biology, 2021 - Elsevier
Gestational exposure to environmental stress induces fetal growth restriction (FGR), and
thereby increasing the risk of infant death and chronic noncommunicable diseases in adults …

[HTML][HTML] Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts

HL Zhu, XT Shi, XF Xu, YW Xiong, SJ Yi, GX Zhou… - Environment …, 2021 - Elsevier
Cadmium (Cd), an environmental toxicant, is positively associated with fetal growth
restriction (FGR). However, the mechanism by which gestational exposure to Cd induces …

Reactive oxygen species-mediated cellular genotoxic stress is involved in 1-nitropyrene-induced trophoblast cycle arrest and fetal growth restriction

B Wang, S Xu, X Lu, L Ma, L Gao, SY Zhang, R Li… - Environmental …, 2020 - Elsevier
nitropyrene (1-NP) is a key component of diesel exhaust-sourced fine particulate matter
(PM2. 5). Our recent study demonstrated that gestational 1-NP exposure caused placental …

Exposure to benzo (a) pyrene suppresses mitophagy via ANT1-PINK1-Parkin pathway in ovarian corpus luteum during early pregnancy

N Li, H Xu, X Liu, R Gao, J He, Y Ding, F Li… - Science of The Total …, 2022 - Elsevier
Exposure to benzo (a) pyrene (BaP) has been confirmed to interfere with embryo
implantation. As the primary organ of progesterone synthesis during early pregnancy, the …

[HTML][HTML] 1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS

Y Liang, Q Shuai, Y Wang, S Jin, Z Feng… - Ecotoxicology and …, 2021 - Elsevier
Haze problem is an important factor threatening human health. PM2. 5 is the main culprit
haze. 1-Nitropyrene (1-NP) is the main nitrated polycyclic aromatic hydrocarbon, the toxic …

[HTML][HTML] Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes

J Li, L Gao, J Chen, WW Zhang, XY Zhang… - Environment …, 2022 - Elsevier
In the past 50 years, testosterone (T) level in men has declined gradually. In this research,
we discovered that acute exposure to 1-nitropyrene (1-NP), an environmental stressor from …

[HTML][HTML] Urban PM2. 5 induces cellular toxicity, hormone dysregulation, oxidative damage, inflammation, and mitochondrial interference in the HRT8 trophoblast cell …

Å Nääv, L Erlandsson, C Isaxon… - Frontiers in …, 2020 - frontiersin.org
Objective: Epidemiological studies have found air pollution to be a driver of adverse
pregnancy outcomes, including gestational diabetes, low term birth weight and …

[HTML][HTML] 1-Nitropyrene exposure induces mitochondria dysfunction and impairs oocyte maturation in mice

X Yu, F Meng, J Huang, W Li, J Zhang, S Yin… - Ecotoxicology and …, 2022 - Elsevier
Oocyte quality is essential for a successful pregnancy. 1-Nitropyrene (1-NP) is a widely
distributed pollutant in the environment and is well-known for its mutagenicity and …

Exposure to Benzo (a) pyrene damages mitochondrial function via suppressing mitochondrial melatonin receptors in ovarian corpus luteum during early pregnancy

J Yang, H Xu, R Gao, X Liu, J He, M Zhou… - Chemico-Biological …, 2022 - Elsevier
Abstract Benzo (a) pyrene (BaP) is a well-known environmental endocrine pollutant, which
has ovarian toxicity in mammals. Ovarian corpus luteum (CL), as the main source of …