Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …

In the periphery insulin plays a critical role in the regulation of metabolic homeostasis by
stimulating glucose uptake into peripheral organs. In the central nervous system (CNS) …

Insulin regulates glucose uptake and storage in peripheral tissues, and has been shown to
act within the hypothalamus to acutely regulate food intake and metabolism. The machinery …

A growing body of animal and epidemiological studies suggest that metabolic diseases such
as obesity, insulin resistance, metabolic syndrome and type 2 diabetes mellitus are …

Cognitive function and peripheral glucose regulation both decrease with age. There is a
consistent and growing literature reporting memory and other cognitive problems among …

Cognitive disorders of aging represent a serious threat to the social and economic welfare of
current society. It is now widely recognized that pathology related to such conditions …

Epidemiologic and biologic studies support a link between type 2 diabetes mellitus and
Alzheimer's disease, but the precise mechanism linking the two remains unclear. Growing …

The escalating obesity/diabetes epidemic is an important health-care issue that has crucial
socio-economic ramifications. The complications of diabetes/obesity phenotypes extend to …

Understanding of the role of insulin in the brain has gradually expanded, from initial
conceptions of the brain as insulin-insensitive through identification of a role in regulation of …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …