Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea

KM Kim, EJ Lee, S Ha, SY Kang, KT Jang… - The American journal …, 2011 - journals.lww.com
Abundant recent data suggest that sessile serrated adenoma/polyp (SSA/P) is an early
precursor lesion in the serrated pathway of carcinogenesis. It is believed that SSA/Ps …

Serrated polyps and colorectal cancer: new pathway to malignancy

AE Noffsinger - Annual Review of Pathology: Mechanisms of …, 2009 - annualreviews.org
Until recently, two major forms of colorectal epithelial polyp were recognized: the adenoma
and the hyperplastic polyp. Adenomas were perceived to represent the precursor to …

Progression of a sessile serrated adenoma to an early invasive cancer within 8 months

Y Oono, K Fu, H Nakamura, Y Iriguchi… - Digestive diseases and …, 2009 - Springer
Recent studies suggest that serrated polyps, including hyperplastic polyps, traditional
serrated adenomas, and sessile serrated adenomas, may be morphologically and …

Association of large serrated polyps with synchronous advanced colorectal neoplasia

D Li, C Jin, C McCulloch, S Kakar… - Official journal of the …, 2009 - journals.lww.com
OBJECTIVES: Serrated polyps of the colorectum are a histologically and genetically
heterogeneous group of lesions, which include classic hyperplasic polyps, sessile serrated …

Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion'pathway to colorectal cancer

JR Jass, K Baker, I Zlobec, T Higuchi, M Barker… - …, 2006 - Wiley Online Library
Aim: To establish and explain the pattern of molecular signatures across colorectal polyps.
Methods and results: Thirty‐two sessile serrated adenomas (SSA), 10 mixed polyps (MP), 15 …

BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status

S Yang, FA Farraye, C Mack, O Posnik… - The American journal …, 2004 - journals.lww.com
The aim of this study was to test the hypothesis that mutations of the oncogenes BRAF or
KRAS are early events in the putative serrated polyp neoplasia pathway and more …

Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)—proposal for diagnostic …

DE Aust, GB Baretton… - Virchows Archiv, 2010 - Springer
Until recently, two major types of colorectal epithelial polyps were distinguished: the
adenoma and the hyperplastic polyp. While adenomas—because of their cytological atypia …

Serrated adenoma of the colorectum and the DNA-methylator phenotype

JR Jass - Nature Clinical Practice Oncology, 2005 - nature.com
Serrated adenomas (SA) of the colorectum show features intermediate between hyperplastic
polyps (HP) and adenomas. HP and SA are related lesions and there is now strong …

Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps

D Sandmeier, J Benhattar, P Martin… - …, 2009 - Wiley Online Library
Aims: To compare the molecular profile of a series of sessile serrated adenomas (SSAs) and
hyperplastic polyps (HPs), in order to distinguish these lesions, SSAs having a potential role …

Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?

D Sandmeier, W Seelentag, H Bouzourene - Virchows Archiv, 2007 - Springer
The distinction between serrated polyps of the colon is complex, particularly between
hyperplastic polyps (HP) and sessile serrated adenomas (SSA). Recent data show that SSA …