Antifungal drug development: challenges, unmet clinical needs, and new approaches
T Roemer, DJ Krysan - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Invasive, life-threatening fungal infections are an important cause of morbidity and mortality,
particularly for patients with compromised immune function. The number of therapeutic …
particularly for patients with compromised immune function. The number of therapeutic …
Potential targets for the development of new antifungal drugs
H Su, L Han, X Huang - The journal of antibiotics, 2018 - nature.com
In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …
immunosuppressed patients, but most today's antifungal drugs are not completely effective …
Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
Antifungal drug discovery: something old and something new
A Butts, DJ Krysan - 2012 - journals.plos.org
Invasive fungal infections are devastating. Despite state-of-theart antifungal therapy, the
mortality rates for invasive infections with the three most common species of human fungal …
mortality rates for invasive infections with the three most common species of human fungal …
Antifungal pipeline
TP McCarty, PG Pappas - Frontiers in cellular and infection …, 2021 - frontiersin.org
In many ways, fungal diseases are forgotten or neglected. Given the significantly lower
frequency compared to similar bacterial etiologies across the spectrum of infectious …
frequency compared to similar bacterial etiologies across the spectrum of infectious …
New horizons in antifungal therapy
KM Pianalto, JA Alspaugh - Journal of Fungi, 2016 - mdpi.com
Recent investigations have yielded both profound insights into the mechanisms required by
pathogenic fungi for virulence within the human host, as well as novel potential targets for …
pathogenic fungi for virulence within the human host, as well as novel potential targets for …
Current antimycotics, new prospects, and future approaches to antifungal therapy
G Wall, JL Lopez-Ribot - Antibiotics, 2020 - mdpi.com
Fungal infections represent an increasing threat to a growing number of immune-and
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …
Emerging new targets for the treatment of resistant fungal infections
N Liu, J Tu, G Dong, Y Wang… - Journal of medicinal …, 2018 - ACS Publications
With the increasing morbidity and mortality of invasive fungal infections and the emergence
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …
Advances in antifungal drug development: an up-to-date mini review
The utility of clinically available antifungals is limited by their narrow spectrum of activity,
high toxicity, and emerging resistance. Antifungal drug discovery has always been a …
high toxicity, and emerging resistance. Antifungal drug discovery has always been a …
Emerging targets for the development of novel antifungal therapeutics
AH Groll, AJ De Lucca, TJ Walsh - Trends in Microbiology, 1998 - cell.com
Invasive mycoses have become important causes of morbidity and mortality in
immunocompromised patients. New approaches for antifungal therapy are required to meet …
immunocompromised patients. New approaches for antifungal therapy are required to meet …