This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

1. This review focuses on the extracellular actions of ATP and adenosine, and in particular
their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the …

Adenosine and adenosine 5′-triphosphate (ATP) are found in every cell of the human
body. These molecules are released from cells into the extracellular fluid under physiologic …

The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …

There is growing evidence for several different roles for purines in the control of blood
flow.(1) Adenosine 5′-triphosphate (ATP) acts as a cotransmitter with noradrenaline and …

ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …

The potent extracellular actions of purne nucleosides and nucleotides were first recognized
by Drury and Szent-Gyorgyi.'Following this report, there was considerable activity within the …

The emphasis in this article is on the growing interest in the pathophysiology and
therapeutic potential of purinergic signalling. 1–8 However, it begins with a review of the …

Adenosine and its phosphorylated nucleotide derivative, ATP, perform essential intracellular
functions in all cells. Because the synthesis of ATP requires the expenditure of metabolic …