The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a
useful strategy for preparing complex molecular structures. After oxidative addition of a …

Abstract Carbon–carbon (C–C) bonds make up the skeletons of most organic molecules.
The selective manipulation of C–C bonds offers a direct approach to editing molecular …

Stimulated by the need for green and more efficient approaches to functionalize
hydrocarbon feedstocks, the vast development of carbon–hydrogen (C–H) bond activation …

Advances in metal catalysis have revolutionized organic synthesis, with the scope of metal‐
catalyzed reactions now covering nearly all areas of carbon–carbon, carbon–hydrogen, and …

Migration of metals along a carbon chain is triggered by two of the most common
organometallic elementary steps–β-hydride (β-H) elimination and alkene hydrometallation …

C− C bond activation has emerged as an increasingly useful approach for constructing
complex molecular scaffolds through unusual bond-disconnection strategies. As a common …

The transition-metal-catalyzed addition of C–H bonds to carbonyls, imines, and related
polarized π bonds has emerged as a particularly efficient and powerful approach for the …

Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

The activation of σ-bonds by transition metals underpins a wide range of methods for the
synthesis of complex molecules. Within this context, C–N bond activation has emerged …

Currently, the construction of new carbon–carbon bonds and value-added structures in an
atom-and step economical manner has become a continuous pursuit in the synthetic …