Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior.
We show here that 4 months and later after nerve injury, male but not female mice displayed …

Telomere length, considered a measure of biological aging, is linked to morbidity and
mortality. Psychosocial factors associated with shortened telomeres are also common in …

In experimental and clinical pain studies, the sex of subjects was rarely taken into account,
even if nociceptive inputs appear to be processed and modulated by partially distinct neural …

Background: Chronic pain conditions are characterized by significant individual variability
complicating the identification of pathophysiological markers. Leukocyte telomere length …

Human epidemiological studies suggest that chronic pain can increase mortality risk. We
investigated whether this was true in mice so that underlying mechanisms might be …

Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

Chronic pain is one of the most common, costly, and potentially debilitating health issues
facing older adults, with attributable costs exceeding $600 billion annually. The prevalence …

Sex differences play a role in pain sensitivity, efficacy of analgesic drugs and prevalence of
neuropathic pain, even if the underlying mechanisms are far from being understood. We …

Reciprocal interactions between stress and pain are well documented. Physical and
psychosocial stressors, including childhood adversity, predict onset and exacerbation of …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …