Methods In silico analysis predicted putative binding sites of core clock components for
Caspase genes. Eighty male Wistar rats were divided into either Sham-operated or …

Background and objectives: Visceral adipocytes, typically larger and more pro-inflammatory
than subcutaneous adipocytes, are less sensitive to insulin action and more susceptible to …

Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian
manner (24‐hr period), and its oscillation influences several circadian biological rhythms …

Melatonin is synthesized in the pineal gland and controls circadian rhythm of peripheral
adipose tissue, resulting in changes in body weight. Although core regulatory components of …

Developing novel drugs/targets remains a major effort toward controlling obesity-related
type 2 diabetes (diabesity). Melatonin controls obesity and improves glucose homeostasis in …

Mitochondrial dysfunction in adipose tissue may contribute to obesity‐related metabolic
derangements such as type 2 diabetes mellitus (T 2 DM). Because mitochondria are a target …

Despite efforts to curb the incidence of obesity and its comorbidities, this condition remains
the fifth leading cause of death worldwide. To identify ways to reduce this global effect, we …

Women usually experience body weight gain with aging, which can put them at risk for many
chronic diseases. Previous studies indicated that melatonin treatment attenuates body …

The sedentary lifestyle of modern society along with the high intake of energetic food has
made obesity a current worldwide health problem. Despite great efforts to study the obesity …

Aims Investigate the role of melatonin on the regulation of body temperature in aged animals
that have impaired melatonin production. Material and methods Aged Male Wistar rats were …