Here, we provide an up-to-date review of the histopathology and molecular pathology of
serrated colorectal lesions. First, we introduce the updated contents of the 2019 World …

Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

The concept of serrated colorectal neoplasia and a serrated pathway to colorectal cancer
(CRC) is relatively new and continuing to evolve, but it has become highly relevant to …

The 2019 World Health Organization (WHO) Classification of Tumours of the Digestive
System (5th edition) introduced the term “sessile serrated lesion”(SSL) to replace the term …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

The precursor lesion for the~ 30% of colon carcinomas developing along the serrated
pathway was first described in detail in 1996, and was named sessile serrated adenoma in …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

Colonoscopy offers incomplete protection from colorectal cancer, particularly in the right
colon. Part of this inadequacy may be related to serrated neoplasia. Serrated polyps of the …

Until 2010, colorectal serrated lesions were generally considered as harmless lesions and
reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However …

Traditional serrated adenoma is one type of colorectal serrated neoplasm and a precursor of
colorectal cancer. We evaluated the pathologic and molecular features of 60 traditional …