Quantitative computed tomographic imaging–based clustering differentiates asthmatic subgroups with distinctive clinical phenotypes
Background Imaging variables, including airway diameter, wall thickness, and air trapping,
have been found to be important metrics when differentiating patients with severe asthma …
have been found to be important metrics when differentiating patients with severe asthma …
[HTML][HTML] Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients
Background Asthma heterogeneity is multidimensional and requires additional tools to
unravel its complexity. Computed tomography (CT)–assessed proximal airway remodeling …
unravel its complexity. Computed tomography (CT)–assessed proximal airway remodeling …
Quantitative CT characteristics of cluster phenotypes in the severe asthma research program cohorts
Background Clustering key clinical characteristics of participants in the Severe Asthma
Research Program (SARP), a large, multicenter prospective observational study of patients …
Research Program (SARP), a large, multicenter prospective observational study of patients …
Differences in particle deposition between members of imaging-based asthma clusters
Background: Four computed tomography (CT) imaging-based clusters have been identified
in a study of the Severe Asthma Research Program (SARP) cohort and have been …
in a study of the Severe Asthma Research Program (SARP) cohort and have been …
Severe Asthma Phenotypes Classified by Site of Airway Involvement and Remodeling via Chest CT Scan.
S Kim, CH Lee, KN Jin, SH Cho… - Journal of investigational …, 2018 - europepmc.org
OBJECTIVES: This study aimed to establish a system that can classify severe asthma on the
basis of airway remodeling patterns visualizedusing computed tomography (CT) images and …
basis of airway remodeling patterns visualizedusing computed tomography (CT) images and …
The relationship of airway structural changes to blood and bronchoalveolar lavage biomarkers, and lung function abnormalities in asthma
P Kozlik, J Zuk, S Bartyzel, J Zarychta… - Clinical & …, 2020 - Wiley Online Library
Background Airway structural changes are important in asthma pathology and require
further investigations. Objective We sought to evaluate which computed tomography (CT) …
further investigations. Objective We sought to evaluate which computed tomography (CT) …
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
Background Severe asthma is a heterogeneous condition. Airway remodelling is a feature of
severe asthma and can be determined by the assessment of high-resolution computed …
severe asthma and can be determined by the assessment of high-resolution computed …
Differentiation of quantitative CT imaging phenotypes in asthma versus COPD
Introduction Quantitative CT (QCT) imaging-based metrics have quantified disease
alterations in asthma and chronic obstructive pulmonary disease (COPD), respectively. We …
alterations in asthma and chronic obstructive pulmonary disease (COPD), respectively. We …
Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: results from SARP-3
Background Currently, there is limited knowledge regarding which imaging assessments of
asthma are associated with accelerated longitudinal decline in lung function. Objectives We …
asthma are associated with accelerated longitudinal decline in lung function. Objectives We …
Is computed tomography airway count related to asthma severity and airway structure and function?
Rationale: In patients with asthma, X-ray computed tomography (CT) has provided evidence
of thickened airway walls and airway occlusions, but the total number of CT-visible airways …
of thickened airway walls and airway occlusions, but the total number of CT-visible airways …