Alphaviruses cause severe arthritogenic or encephalitic disease. The E1 structural
glycoprotein is highly conserved in these viruses and mediates viral fusion with host cells …

We have previously identified at least eight epitopes on the E2 glycoprotein of Venezuelan
equine encephalomyelitis (VEE) virus vaccine strain TC-83 by using monoclonal antibodies …

A panel of four monoclonal antibodies (mAb) were produced that cross-react with
representatives of two different togavirus serogroups, namely sindbis (SIN) and Semliki …

Selection and development of monoclonal antibody (mAb) therapeutics against pathogenic
viruses depends on certain functional characteristics. Neutralization potency, or the half …

Alphaviruses are emerging, mosquito-transmitted pathogens that cause musculoskeletal
and neurological disease in humans. Although neutralizing antibodies that inhibit individual …

Although neutralizing monoclonal antibodies (mAbs) against epitopes within the alphavirus
E2 protein can protect against infection, the functional significance of non-neutralizing mAbs …

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high
case mortality rate in humans. EEEV is a biodefence concern because of its potential for …

Background Venezuelan equine encephalitis virus (VEEV) is responsible for VEE epidemics
that occur in South and Central America and the US The VEEV envelope contains two …

We screened a panel of mouse and human monoclonal antibodies (MAbs) against
chikungunya virus and identified several with inhibitory activity against multiple …

The development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel
therapeutic options for infectious disease. In addition to preventing viral infection through …