Melanoma in a patient with DNMT3A overgrowth syndrome
Alterations in epigenetic regulators are increasingly recognized as early events in
tumorigenesis; thus, patients with acquired or inherited variants in epigenetic regulators may …
tumorigenesis; thus, patients with acquired or inherited variants in epigenetic regulators may …
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype
DY Chen, IM Ferguson, KA Braun… - Proceedings of the …, 2021 - National Acad Sciences
DNA hypomethylation is a feature of epidermal cells from aged and sun-exposed skin, but
the mechanisms responsible for this methylation loss are not known. Dnmt3a is the …
the mechanisms responsible for this methylation loss are not known. Dnmt3a is the …
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies
CB Cole, DA Russler-Germain, S Ketkar… - The Journal of …, 2017 - Am Soc Clin Investig
The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability
K Tatton-Brown, S Seal, E Ruark, J Harmer… - Nature …, 2014 - nature.com
Overgrowth disorders are a heterogeneous group of conditions characterized by increased
growth parameters and other variable clinical features such as intellectual disability and …
growth parameters and other variable clinical features such as intellectual disability and …
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice
K Lopusna, P Nowialis, J Opavska, A Abraham… - Journal of Biological …, 2021 - ASBMB
DNA methylation regulates gene transcription and is involved in various physiological
processes in mammals, including development and hematopoiesis. It is catalyzed by DNA …
processes in mammals, including development and hematopoiesis. It is catalyzed by DNA …
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis
MY Shah, A Vasanthakumar, NY Barnes, ME Figueroa… - Cancer research, 2010 - AACR
Epigenetic changes are among the most common alterations observed in cancer cells, yet
the mechanism by which cancer cells acquire and maintain abnormal DNA methylation …
the mechanism by which cancer cells acquire and maintain abnormal DNA methylation …
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome
Germline pathogenic variants in DNMT3A were recently described in patients with
overgrowth, obesity, behavioral, and learning difficulties (D NMT3A O vergrowth S …
overgrowth, obesity, behavioral, and learning difficulties (D NMT3A O vergrowth S …
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis
SL Haney, RA Hlady, J Opavska, D Klinkebiel… - Oncogene, 2015 - nature.com
Abstract DNA methyltransferase 3A (DNMT3A) catalyzes cytosine methylation of mammalian
genomic DNA. In addition to myeloid malignancies, mutations in DNMT3A have been …
genomic DNA. In addition to myeloid malignancies, mutations in DNMT3A have been …
[HTML][HTML] DNMT3A R882H overexpression leads to hematopoietic and skin alterations in transgenic mice
Somatic mutations in the DNA methyltransferase gene, DNMT3A, have been identified in>
30% of de novo AML cases with a normal karyotype, and in> 10% of patients with MDS. To …
30% of de novo AML cases with a normal karyotype, and in> 10% of patients with MDS. To …
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
A Vasanthakumar, JB Lepore… - Blood, The Journal …, 2013 - ashpublications.org
The drivers of abnormal DNA methylation in human cancers include widespread aberrant
splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated …
splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated …