Objectives Exosome-mediated reciprocal crosstalk between tumor and stromal cells plays a
crucial role in tumor development and progression. This study investigated whether …

Stroma–cancer cell crosstalk involves a complex signaling network that contributes to tumor
progression, including carcinogenesis, angiogenesis, migration, invasion, and therapy …

Background Exosomes are cell-derived vesicles that mediate cellular communication in
health and multiple diseases, including cancer. However, its role in head and neck cancer …

Abstract Background Cancer-associated fibroblasts (CAFs) have significant tumor regulatory
functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important …

Oral cancer constitutes approximately 2% of all cancers, while the most common type, oral
squamous cell carcinoma (OSCC) represents 90% of oral cancers. Although the treatment of …

Background In tumor microenvironment, a continuous cross-talk between cancer cells and
other cellular components is required to sustain tumor progression. Accumulating evidence …

Exosomes are small membranous vesicles that contain proteins, lipids, genetic material, and
metabolites with abundant information from parental cells. Exosomes carry and deliver …

Mesenchymal stem cells (MSCs), which are capable of differentiating into multiple cell types,
are reported to exert multiple effects on tumor development. However, the relationship …

Cancer-cell-derived exosomes confer oncogenic properties in their tumor microenvironment
and to other cells; however, the exact mechanism underlying this process is unclear. Here …

Salivary adenoid cystic carcinoma (SACC) is a rare head and neck malignancy
characterized by unpredictable expansion, considerable perineural invasion and high risk of …