The promise and challenges of developing miRNA-based therapeutics for Parkinson's disease

SS Titze-de-Almeida, C Soto-Sánchez, E Fernandez… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-
specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of …

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease

OA Mohammed, MS Elballal, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Parkinson's disease (PD) is a debilitating neurological disorder characterized by the
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …

Advances with microRNAs in Parkinson's disease research

L Ma, L Wei, F Wu, Z Hu, Z Liu… - Drug design, development …, 2013 - Taylor & Francis
Parkinson's disease (PD) is the second-most common age-dependent neurodegenerative
disorder and is caused by severe degeneration of dopaminergic neurons in the substantia …

[HTML][HTML] MicroRNAs in the epigenetic regulation of disease progression in Parkinson's disease

SC Selvakumar, KA Preethi, D Tusubira… - Frontiers in Cellular …, 2022 - frontiersin.org
Parkinson's disease (PD) is a multifactorial neurodegenerative condition with symptoms
such as resting tremor, rigidity, bradykinesia (slowness of moment), and postural instability …

Involvement of miRNA on epigenetics landscape of Parkinson's disease: From pathogenesis to therapeutics

SN Uppala, KP Tryphena, P Naren, S Srivastava… - Mechanisms of Ageing …, 2023 - Elsevier
The development of novel therapeutics for the effective management of Parkinson's disease
(PD) is undertaken seriously by the scientific community as the burden of PD continues to …

[HTML][HTML] MicroRNA dysregulation in Parkinson's disease: a narrative review

YH Nies, NH Mohamad Najib, WL Lim… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a severely debilitating neurodegenerative disease, affecting the
motor system, leading to resting tremor, cogwheel rigidity, bradykinesia, walking and gait …

miRNA in Parkinson's disease: From pathogenesis to theranostic approaches

A Elangovan, D Venkatesan, P Selvaraj… - Journal of Cellular …, 2023 - Wiley Online Library
Parkinson's disease (PD) is an age associated neurological disorder which is specified by
cardinal motor symptoms such as tremor, stiffness, bradykinesia, postural instability, and non …

Role of MicroRNAs in Parkinson's disease

SY Goh, YX Chao, ST Dheen, EK Tan… - International journal of …, 2019 - mdpi.com
Parkinson's disease (PD) is a disabling neurodegenerative disease that manifests with
resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of …

microRNAs in Parkinson's disease: from pathogenesis to novel diagnostic and therapeutic approaches

L Leggio, S Vivarelli, F L'Episcopo, C Tirolo… - International journal of …, 2017 - mdpi.com
Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …

[HTML][HTML] MicroRNAs play a role in Parkinson's disease by regulating microglia function: from pathogenetic involvement to therapeutic potential

S Li, G Bi, S Han, R Huang - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is a clinically common neurodegenerative disease of the central
nervous system (CNS) characterized by loss of dopamine neurons in the substantia nigra …