The cholinergic system plays an essential role in brain development, physiology, and
pathophysiology. Herein, we review how specific alterations in this system, through genetic …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Mammalian nicotinic acetylcholine receptors (nAChRs) were initially discovered as ligand-
gated ion channels mediating fast synaptic transmission in the neuro-muscular junctions …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Mapping of nicotinic acetylcholine receptor (nAChR) subtypes and subunits in human brain
is far from complete, however it is clear that multiple subunits are present (including α3, α4 …

The focus of this chapter is the neurobiological basis for the neurotropic and neurotoxic
aspects of nicotine via modulation of the nicotine receptor. The nicotine receptor, also known …

Drug addiction is a chronic neuropsychiatric disorder which is characterized by a
compulsion to take drugs and loss of control in limiting intake. The worldwide impact of drug …

Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate
in diverse functions: reward, learning and memory, mood, sensory processing, pain, and …

Alzheimer's disease (AD) is a neurodegenerative condition characterized by increased
accumulation of Aβ and degeneration of cholinergic signaling between basal forebrain and …

Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …