For the past 30 years, the standard of care for epithelial ovarian cancer has essentially
remained unchanged with little progress in the development of novel innovative treatments …

High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of
epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the …

Introduction: Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, and its
five-year survival rate has not changed appreciably in decades. As such, there is an …

Purpose: Statins are among the most frequently prescribed drugs because of their efficacy
and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to …

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer and often is not
detected until late stages when cancer cells transcoelomically metastasize to the abdomen …

Simple Summary For tumors to initiate and sustain rapid growth, they need to alter their
metabolic reprograming to support this growth. While many oncogenes upregulate …

Background Ovarian cancer remains the most fatal gynecological malignancy. Current
therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic …

Background Ovarian carcinoma is a rarely curable disease, for which new treatment options
are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the …

Ovarian cancer is the 5th leading cause of cancer death among women in the United States.
The mevalonate pathway is thought to be a potential oncogenic pathway in the …

Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol
have suggested that statins may be useful to treat cancer. However, prospective clinical …