Osteosarcoma (OS) is the most common primary bone cancer in children and young adults.
This type of cancer is characterized by a high mortality rate, especially for patients with …

Simple Summary This review explores various studies to understand how 3D cell cultures
mimic real tumour conditions and respond to anticancer drugs. This study focuses on …

Osteosarcoma (OS) is the most common primary malignant tumor of bone that mainly affects
children and adolescents. The currently available therapies are not effective and the search …

Osteosarcoma (OS) is a highly aggressive primary bone tumor. The mainstay for its
treatment is multiagent chemotherapy and surgical resection, with a 50–70% 5-year survival …

Simple Summary Osteosarcoma (OS) is the most common bone tumor in the pediatric
population. Currently, no effective molecularly targeted therapies are available for OS. The …

Osteosarcoma (OS) is the most common primary malignant tumor of bone, which
preferentially develops lung metastasis. Although standard chemotherapy has significantly …

Bone primary tumors, such as osteosarcoma, are highly aggressive pediatric tumors that in
30% of the cases develop lung metastasis and are characterized by poor prognosis. Bone is …

Osteosarcoma (OS) is the most common primary bone cancer, where the overall 5‐year
surviving rate is below 20% in resistant forms. Accelerating cures for those poor outcome …

Investigations of cancer biology and screening of potential therapeutics for efficacy and
safety begin in the preclinical laboratory setting. A staple of most basic research in cancer …

Cancer metastasis to bone is a three-dimensional (3D), multistep, dynamic process that
requires the sequential involvement of three microenvironments, namely, the primary tumour …