Bioconjugation by copper (I)-catalyzed azide-alkyne [3+ 2] cycloaddition
The copper-catalyzed cycloaddition reaction between azides and alkynes functions
efficiently in aqueous solution in the presence of a tris (triazolyl) amine ligand. The process …
efficiently in aqueous solution in the presence of a tris (triazolyl) amine ligand. The process …
Copper‐catalyzed azide–alkyne click chemistry for bioconjugation
The copper‐catalyzed azide‐alkyne cycloaddition reaction is widely used for the connection
of molecular entities of all sizes. A protocol is provided here for the process with …
of molecular entities of all sizes. A protocol is provided here for the process with …
[HTML][HTML] Analysis and optimization of copper-catalyzed azide–alkyne cycloaddition for bioconjugation
Since its discovery in 2002, the copper-catalyzed azide-alkyne cycloaddition (CuAAC)[1]
reaction—the most widely recognized example of click chemistry [2]—has been rapidly …
reaction—the most widely recognized example of click chemistry [2]—has been rapidly …
Labeling live cells by copper-catalyzed alkyne− azide click chemistry
The copper-catalyzed azide− alkyne cycloaddition (CuAAC) reaction, optimized for
biological molecules in aqueous buffers, has been shown to rapidly label mammalian cells …
biological molecules in aqueous buffers, has been shown to rapidly label mammalian cells …
Electrochemically Protected Copper (I)‐Catalyzed Azide–Alkyne Cycloaddition
The copper (I)‐catalyzed azide–alkyne cycloaddition (CuAAC) reaction has found broad
application in myriad fields. For the most demanding applications that require high yields at …
application in myriad fields. For the most demanding applications that require high yields at …
[PDF][PDF] Metal-free triazole formation as a tool for bioconjugation
SS Van Berkel, AJ Dirks, MF Debets, FL van Delft… - 2007 - repository.ubn.ru.nl
The development of selective and site-specific bio-orthogonal conjugation methods is an
important topic in chemical biology. A wide range of methods, such as the Staudinger …
important topic in chemical biology. A wide range of methods, such as the Staudinger …
Relative performance of alkynes in copper-catalyzed azide–alkyne cycloaddition
AA Kislukhin, VP Hong, KE Breitenkamp… - Bioconjugate …, 2013 - ACS Publications
Copper-catalyzed azide–alkyne cycloaddition (CuAAC) has found numerous applications in
a variety of fields. We report here only modest differences in the reactivity of various classes …
a variety of fields. We report here only modest differences in the reactivity of various classes …
Copper‐chelating azides for efficient click conjugation reactions in complex media
V Bevilacqua, M King, M Chaumontet… - Angewandte …, 2014 - Wiley Online Library
The concept of chelation‐assisted copper catalysis was employed for the development of
new azides that display unprecedented reactivity in the copper (I)‐catalyzed azide–alkyne …
new azides that display unprecedented reactivity in the copper (I)‐catalyzed azide–alkyne …
Sulfated Ligands for the Copper (I)‐Catalyzed Azide–Alkyne Cycloaddition
The copper (I)‐catalyzed azide–alkyne cycloaddition (CuAAC), the prototypical reaction of
click chemistry, is accelerated by tris (triazolylmethyl) amine‐based ligands. Herein, we …
click chemistry, is accelerated by tris (triazolylmethyl) amine‐based ligands. Herein, we …
[HTML][HTML] Peptide conjugation via CuAAC 'click'chemistry
The copper (I)-catalyzed alkyne azide 1, 3-dipolar cycloaddition (CuAAC) or 'click'reaction, is
a highly versatile reaction that can be performed under a variety of reaction conditions …
a highly versatile reaction that can be performed under a variety of reaction conditions …