Bioconjugation by copper (I)-catalyzed azide-alkyne [3+ 2] cycloaddition

Q Wang, TR Chan, R Hilgraf, VV Fokin… - Journal of the …, 2003 - ACS Publications
The copper-catalyzed cycloaddition reaction between azides and alkynes functions
efficiently in aqueous solution in the presence of a tris (triazolyl) amine ligand. The process …

Copper‐catalyzed azide–alkyne click chemistry for bioconjugation

SI Presolski, VP Hong, MG Finn - Current protocols in chemical …, 2011 - Wiley Online Library
The copper‐catalyzed azide‐alkyne cycloaddition reaction is widely used for the connection
of molecular entities of all sizes. A protocol is provided here for the process with …

[HTML][HTML] Analysis and optimization of copper-catalyzed azide–alkyne cycloaddition for bioconjugation

V Hong, SI Presolski, C Ma, MG Finn - … Chemie (International ed. in …, 2009 - ncbi.nlm.nih.gov
Since its discovery in 2002, the copper-catalyzed azide-alkyne cycloaddition (CuAAC)[1]
reaction—the most widely recognized example of click chemistry [2]—has been rapidly …

Labeling live cells by copper-catalyzed alkyne− azide click chemistry

V Hong, NF Steinmetz, M Manchester… - Bioconjugate …, 2010 - ACS Publications
The copper-catalyzed azide− alkyne cycloaddition (CuAAC) reaction, optimized for
biological molecules in aqueous buffers, has been shown to rapidly label mammalian cells …

Electrochemically Protected Copper (I)‐Catalyzed Azide–Alkyne Cycloaddition

V Hong, AK Udit, RA Evans, MG Finn - ChemBioChem, 2008 - Wiley Online Library
The copper (I)‐catalyzed azide–alkyne cycloaddition (CuAAC) reaction has found broad
application in myriad fields. For the most demanding applications that require high yields at …

[PDF][PDF] Metal-free triazole formation as a tool for bioconjugation

SS Van Berkel, AJ Dirks, MF Debets, FL van Delft… - 2007 - repository.ubn.ru.nl
The development of selective and site-specific bio-orthogonal conjugation methods is an
important topic in chemical biology. A wide range of methods, such as the Staudinger …

Relative performance of alkynes in copper-catalyzed azide–alkyne cycloaddition

AA Kislukhin, VP Hong, KE Breitenkamp… - Bioconjugate …, 2013 - ACS Publications
Copper-catalyzed azide–alkyne cycloaddition (CuAAC) has found numerous applications in
a variety of fields. We report here only modest differences in the reactivity of various classes …

Copper‐chelating azides for efficient click conjugation reactions in complex media

V Bevilacqua, M King, M Chaumontet… - Angewandte …, 2014 - Wiley Online Library
The concept of chelation‐assisted copper catalysis was employed for the development of
new azides that display unprecedented reactivity in the copper (I)‐catalyzed azide–alkyne …

Sulfated Ligands for the Copper (I)‐Catalyzed Azide–Alkyne Cycloaddition

W Wang, S Hong, A Tran, H Jiang… - Chemistry–An Asian …, 2011 - Wiley Online Library
The copper (I)‐catalyzed azide–alkyne cycloaddition (CuAAC), the prototypical reaction of
click chemistry, is accelerated by tris (triazolylmethyl) amine‐based ligands. Herein, we …

[HTML][HTML] Peptide conjugation via CuAAC 'click'chemistry

AAH Ahmad Fuaad, F Azmi, M Skwarczynski, I Toth - Molecules, 2013 - mdpi.com
The copper (I)-catalyzed alkyne azide 1, 3-dipolar cycloaddition (CuAAC) or 'click'reaction, is
a highly versatile reaction that can be performed under a variety of reaction conditions …