Cadmium (Cd) is a significant environmental contaminant known for its potential hepatotoxic
effects. However, the precise mechanisms underlying Cd-induced hepatotoxicity have yet to …

Cadmium is an important environmental pollutant that poses a serious threat to the health of
humans and animals. A large number of studies have shown that the liver is one of the …

Gap junction protein connexin 43 (Cx43) plays a critical role in gap junction communication
in rat hepatocytes. However, those located between hepatocytes are easily internalized …

Primary hepatocyte cultures suffer from the progressive occurrence of dedifferentiation
followed by spontaneous apoptosis. This is associated with modifications in the expression …

Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

Objective: Liver fibrosis results from the perpetuation of the normal wound healing response
to several types of injury. Despite the wealth of knowledge regarding the involvement of …

In normal liver, Connexin (Cx) 43 is not detected, but up-regulated in some liver cancers. We
herein investigated the role of Cx43 in hepatoma cell carcinogenesis. Cx43-silenced HuH7 …

We investigated the potential involvement of connexin hemichannels in cadmium ions
(Cd2+)-elicited cell injury. Transfection of LLC-PK1 cells with a wild-type connexin43 (Cx43) …

Cadmium (Cd) is known to induce hepatotoxicity, yet the underlying mechanism of how this
occurs is not fully understood. In this study, Cd-induced apoptosis was demonstrated in rat …

Gap junction channels, formed by connexins (Cx), are involved in the maintenance of tissue
homeostasis, cell growth, differentiation, and development. Several studies have shown that …