Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …

Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia
risk, providing methods for quantifying schizophrenia polygenic risk based on common …

Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …

It has long been recognized that generalized deficits in cognitive ability represent a core
component of schizophrenia (SCZ), evident before full illness onset and independent of …

General cognitive (intelligence) function is substantially heritable, and is a major
determinant of economic and health-related life outcomes. Cognitive impairments and …

Context The use of endophenotypes, biological traits that increase the liability to a disorder,
represents one strategy to facilitate the detection of susceptibility genes for complex …

Background Cognitive impairment is a clinically important feature of schizophrenia.
Polygenic risk score (PRS) methods have demonstrated genetic overlap between …

Content TheDSM-IVconcept of schizophrenia offers diagnostic reliability but etiologic and
pathologic heterogeneity, which probably contributes to the inconsistencies in genetic …

Objective: Deficits in neurocognitive function have been demonstrated in individuals with
schizophrenia and in the unaffected family members of these individuals. Genetic studies of …

Importance We investigated the variation in neuropsychological function explained by risk
alleles at the psychosis susceptibility geneZNF804Aand its interacting partners using single …